| CAS
NO. |
564-25-0 (Base)
24390-14-5 (hyclate)
17086-28-1(monohydrate)
94088-85-4 (calcium) |
|
| EINECS
NO. |
209-271-1 |
| FORMULA |
C22H24N2O8·HCl·1/2(H2O)·1/2(C2H6O) |
| MOL
WT. |
512.94 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Doxycycline hydrochloride hemiethanolate hemihydrate;
|
| 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-
6-methyl- 1,11-dioxo-2-naphthacenecarboxamide; |
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
yellowish
crystalline powder |
| MELTING
POINT |
|
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
soluble |
| pH |
2
- 3 |
| VAPOR
DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
Health: 1 Flammability: 0 Reactivity: 0 |
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION AND APPLICATIONS
|
|
Doxycycline is a semisynthetic broad-spectrum antibiotic or antibacterial
belongs to the tetracycline family. It is used treat urinary tract infections,
gum disease, and bacterial infections such as gonorrhea, chlamydia and Bacillus
anthracis. It is also used to treat acne. Doxycycline is available in complex
salt of hydrochloride, hemiethanolate, and hemihydratehyclate for oral administration and for
intravenous use. Doxycycline hyclate is a yellowish crystalline powder; soluble
in water. Doxycycline will not degrade into an epianhydro form. The chemcial
designation is 4-(Dimethylamino)-1, 4, 4a, 5, 5a, 6, 11,
12a-octahydro- 3,5,10,12,12a-pentahydroxy-6-methyl-1,
11-dioxo-2-naphthacenecarboxamide Tetracyclines inhibit bacterial protein
synthesis by binding to the 30S ribosomal subunit. They acts as growth
inhibitors (bacteriostatic) rather than killer of the infectious agent
(bacteriocidal) and are only effective against multiplying microorganisms.
Tetracycline antibiotics include;
- Chlortetracycline (CAS # : 57-62-5)
- Demeclocycline Hydrochloride (CAS # : 64-73-3)
- Demethylchlortetracycline (CAS # : 127-33-3)
- Dihydrostreptomycin Sesquisulfate (CAS # : 5490-27-7)
- Doxycycline (CAS # : 564-25-0)
- Duramycin (CAS # : 1391-36-2)
- Meclocycline Sulfosalicylate (CAS # : 73816-42-9)
- Methacycline
Hydrochloride (CAS # : 3963-95-9)
- Minocycline (CAS # : 10118-90-8)
- Neomycin (CAS # : 1404-04-2)
- Oxytetracycline (CAS # : 6153-64-6)
- Streptomycin (CAS # : 57-92-1)
- Tetracycline (CAS # : 60-54-8)
- Vancomycin (CAS # : 123409-00-7)
|
| SALES
SPECIFICATION (BP2000) |
|
APPEARANCE
|
yellowish
crystalline powder |
| ASSAY |
99.0%
min |
|
pH
|
2
- 3
|
|
OPTICAL
ROTATION
|
-105°
~ -120°
|
|
ETHANOL
|
4.5
- 6.0%
|
|
WATER
|
1.4
- 2.8%
|
|
HEAVY
METALS
|
20ppm
max
|
|
ASH
|
0.5%
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD
CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
Hazard Symbols: XN, Risk Phrases: 22-36/37/38,
Safety Phrases: 26
PRICE
INFORMATION
 |
